DrugTargetSeqR: a genomics- and CRISPR-Cas9–based method to analyze drug targets
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چکیده
منابع مشابه
DrugTargetSeqR: a genomics- and CRISPR/Cas9-based method to analyze drug targets
To identify physiological targets of drugs and bioactive small molecules, we developed an approach, named DrugTargetSeqR, which combines high-throughput sequencing, computational mutation discovery and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9-based genome editing. We applied this approach to ispinesib and YM155, drugs that have undergone clinical trials as antican...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2014
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1551